Experience with nalidixic Acid in the treatment of urinary tract infections of children.

The drug has been shown to be effective in combating most Gram-negative micro-organisms, including Esch. coli, Klebsiella, and B. proteus, in vitro and in vivo (Barlow, 1963; Buchbinder, Webb, and McCabe, 1962; Lesher et al., 1962), though Pseudomnonas appears to be more resistant (Barlow, 1963; Buchbinder et al., 1962; Harper and Howse, 1964). Gram-positive bacteria such as staphylococci, enterococci, and streptococci have been described as resistant to nalidixic acid, when tested by the disc sensitivity method; however, satisfactory clinical responses to the drug have been shown by patients with these types of infections (Campbell, Thomley, and Parsons, 1964; Carroll, 1963; Zinsser, Dubow, and Seneca, 1964). No severe reactions have been observed after the administration of nalidixic acid. Gastro-intestinal disturbances and vertigo (Auvray, 1964; Carroll, 1963; Harper and Howse, 1964; Reimann-Hunziker and Reimann-Hunziker, 1964; Slade, 1963), revers-